KMID : 0372919920130020147
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Journal of Biomedical Engineering Research 1992 Volume.13 No. 2 p.147 ~ p.154
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Synthesis and Physical Properties of New Biodegradable Polyester-Polypeptide Copolymer
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Sung YK
Park CH/SongDK/Jung JH
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Abstract
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Poly (glycolic aclu-co-glycine-L-lactic aclu) has been prepared by rlng opening polymerlzation. The monomer 6-methyl morpholine-2, 5-dlone was synthe-slzed by bromoproplonylation of 2 bromopropionyl bromide with glycine. Glycolide and 6-methyl morpholine-2, 5-dione have been used as starling materials for polydepsipeptides. The synthesized copolymers have been Identlrled by NMR and FT-lR spectrophotometer. The Tg value of poly(glycollc aclu-co glycine-L-tactic acld ) Is In creased with increasing mole fraction of 6-methylmorpholine-2, 5-dlone(60-84¡É). The glass trasltion temperature of poly(glycolic acid-co-glycine-L-lactic-acid) (62-86¡É ) is lower than that of poly (L-lactic acrid-co-glycine-L-lactic acid ). The thermal degradation of poly( L-lactic acid-co- glycine-L-lactic acid ) Is decreased with increasing mole fraction of L-lactide. The thermal degrada pion of poly(glycolic acrid-co-91ycine-L-lactic aclu ) is increased with increasing mole Fraction of glycolide.
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